Acromegaly

  • Alternative Names

    Somatotroph adenoma; Growth hormone excess; Pituitary giant


    Symptoms
    • Body odor
    • Carpal tunnel syndrome
    • Decreased muscle strength (weakness)
    • Easy fatigue
    • Enlarged bones of the face
    • Enlarged feet
    • Enlarged hands
    • Enlarged glands in the skin (sebaceous glands)
    • Enlarged jaw (prognathism) and tongue
    • Excessive height (when excess growth hormone production begins in childhood)
    • Excessive sweating
    • Headache
    • Hoarseness
    • Joint pain
    • Limited joint movement
    • Sleep apnea
    • Swelling of the bony areas around a joint
    • Thickening of the skin, skin tags
    • Widely spaced teeth
    • Widened fingers or toes due to skin overgrowth with swelling, redness, and pain

    Other symptoms that may occur with this disease:

    • Excess hair growth in females
    • Weight gain (unintentional)

    Signs and tests
    • High growth hormone level
    • High insulin-like growth factor 1 (IGF-1) level
    • Spine x-ray shows abnormal bone growth
    • Pituitary MRI may show a pituitary tumor
    • Echocardiogram may show an enlarged heart, leaky mitral valve, or leaky aortic valve

    This disease may also change the results of the following tests:

    • Fasting plasma glucose
    • Glucose tolerance test