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Acute cytomegalovirus (CMV) infection

  • Alternative Names

    CMV mononucleosis; Cytomegalovirus (CMV)


    Most patients recover in 4 - 6 weeks without medication. Rest is needed, sometimes for a month or longer to regain full activity levels. Painkillers and warm salt water gargles can help relieve symptoms.

    Antiviral medications are usually not used in people with normal immune function.

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    Expectations (prognosis)

    Fever usually goes away in 10 days, and swollen lymph glands and spleen return to normal in 4 weeks. Fatigue may linger for 2 to 3 months.


    Throat infection is the most common complication. Rare complications include:

    • Colitis
    • Guillain-Barr√© syndrome
    • Neurologic complications
    • Pericarditis or myocarditis
    • Pneumonia
    • Rupture of spleen

    Calling your health care provider

    Call for an appointment with your health care provider if you have symptoms of acute CMV infection.

    Go to the emergency room or call the local emergency number (such as 911) if you have sharp, sudden pain in your left upper abdomen. This could indicate a ruptured spleen, which requires emergency surgery.