Acute tubular necrosis is a kidney disorder involving damage to the tubule cells of the kidneys, resulting in
Necrosis - renal tubular; ATN; Necrosis - acute tubular
Causes, incidence, and risk factors
Acute tubular necrosis (ATN) is caused by lack of oxygen to the kidney tissues (ischemia of the kidneys).
The internal structures of the kidney, particularly the tissues of the kidney tubule, become damaged or destroyed. ATN is one of the most common structural changes that can lead to acute renal failure.
ATN is one of the most common causes of kidney failure in hospitalized patients. Risks for acute tubular necrosis include:
Blood transfusion reaction
- Injury or trauma that damages the muscles
- Recent major surgery
Septic shockor other forms of shock
- Severe low blood pressure (hypotension) that lasts longer than 30 minutes
Liver disease and kidney damage caused by diabetes (
ATN can be caused by:
- Exposure to medications that are toxic to the kidneys (such as aminoglycoside antibiotics)
- Antifungal agents (such as amphotericin)
- Dye used for x-ray (radiographic) studies