Addison's disease is a disorder that occurs when the
Adrenocortical hypofunction; Chronic adrenocortical insufficiency; Primary adrenal insufficiency
Causes, incidence, and risk factors
The adrenal glands are small hormone-secreting organs located on top of each kidney. They consist of the outer portion (called the cortex) and the inner portion (called the medulla).
The cortex produces three types of hormones:
- The glucocorticoid hormones (such as cortisol) maintain sugar (glucose) control, decrease (suppress)
immune response, and help the body respond to stress.
- The mineralocorticoid hormones (such as aldosterone) regulate sodium and potassium balance.
- The sex hormones, androgens (male) and estrogens (female), affect sexual development and sex drive.
Addison's disease results from damage to the adrenal cortex. The damage causes the cortex to produce less of its hormones.
This damage may be caused by the following:
- The immune system mistakenly attacking the gland (autoimmune disease)
- Infections such as
tuberculosis, HIV, or fungal infections
- Hemorrhage, blood loss
- Use of blood-thinning drugs (anticoagulants)
Risk factors for the autoimmune type of Addison's disease include other
Chronic thyroiditis Dermatis herpetiformis Graves' disease Hypoparathyroidism Hypopituitarism Myasthenia gravis Pernicious anemia
- Testicular dysfunction
Type I diabetes Vitiligo
Certain genetic defects may cause these conditions.