Progressive neuropathic (peroneal) muscular atrophy; Hereditary peroneal nerve dysfunction; Neuropathy - peroneal (hereditary); Hereditary motor and sensory neuropathy
Symptoms usually begin between mid-childhood and early adulthood. They may include:
- Foot deformity (very high arch to feet)
- Foot drop (inability to hold foot horizontal)
- Loss of lower leg muscle, which leads to skinny calves
- Numbness in the foot or leg
- "Slapping" gait (feet hit the floor hard when walking)
Weaknessof the hips, legs, or feet
Later, similar symptoms may appear in the arms and hands, which may include a claw-like hand deformity.
Signs and tests
A physical exam may show:
- Difficulty lifting up the foot and making toe-out movements
- Lack of stretch reflexes in the legs
- Loss of muscle control and atrophy (shrinking of the muscles) in the foot or leg
- Thickened nerve bundles under the skin of the legs
Genetic testing is available for most forms of the disease.