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Congenital spherocytic anemia

  • Alternative Names

    Hereditary spherocytosis; Spherocytosis


    Symptoms

    Infants may have yellowing of the skin and eyes (jaundice) and pale coloring (pallor).

    Other symptoms may include:

    • Fatigue
    • Irritability
    • Shortness of breath
    • Weakness

    Signs and tests

    In most cases, the spleen is enlarged.

    Laboratory tests can help diagnose this condition. Tests may include:

    • Blood smear to show abnormally shaped cells
    • Bilirubin level
    • Complete blood count to check for anemia
    • Coombs' test
    • LDH level
    • Osmotic fragility
    • Reticulocyte count