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Cushing syndrome due to adrenal tumor

  • Alternative Names

    Adrenal tumor - Cushing syndrome


    Symptoms

    Symptoms usually include:

    • Upper body obesity (above the waist) and thin arms and legs
    • Round, red, full face (moon face)
    • Slow growth rate in children

    Skin changes that are often seen:

    • Acne or skin infections
    • Purple marks (1/2 inch or more wide), called striae, on the skin of the abdomen, thighs, and breasts
    • Thin skin with easy bruising

    Muscle and bone changes include:

    • Backache, which occurs with routine activities
    • Bone pain or tenderness
    • Collection of fat between the shoulders (buffalo hump)
    • Thinning of the bones, which leads to rib and spine fractures
    • Weak muscles

    Women often have:

    • Excess hair growth on the face, neck, chest, abdomen, and thighs
    • Menstrual cycle becomes irregular or stops

    Men may have:

    • Decreased fertility
    • Decreased or no desire for sex
    • Impotence

    Other symptoms that may occur include:

    • Mental changes, such as depression, anxiety, or changes in behavior
    • Fatigue
    • Headache
    • High blood pressure
    • Increased thirst and urination

    Signs and tests

    Tests to confirm Cushing syndrome:

    • 24-hour urine sample to measure the following:
      • Urine cortisol
      • Urine creatinine
    • Dexamethasone suppression test
    • Serum cortisol levels

    Tests to determine cause:

    • Abdominal CT
    • ACTH
    • High-dose dexamethasone suppression test

    Other findings may include:

    • High cholesterol
    • High fasting glucose
    • Low bone density, seen by dual x-ray absorptiometry (DEXA)
    • Low serum potassium