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Distal renal tubular acidosis

  • Definition

    Distal renal tubular acidosis is a disease that occurs when the kidneys don't remove acid properly into the urine, leaving the blood too acidic (called acidosis).


    Alternative Names

    Renal tubular acidosis - distal; Renal tubular acidosis type I; Type I RTA; RTA - distal; Classical RTA


    Causes, incidence, and risk factors

    Your kidneys normally regulate your body's pH by removing acids from the blood and discarding them into the urine.

    Distal renal tubular acidosis (Type I RTA) is caused by a defect in the kidney tubes that causes acid to build up in the bloodstream.

    Type I RTA is caused by a variety of conditions, including:

    • Amyloidosis
    • Fabry disease
    • Sickle cell disease
    • Sjogren syndrome
    • Systemic lupus erythematosus
    • Wilson disease
    • Use of certain drugs such as amphotericin B, lithium, and analgesics