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Factor V deficiency

  • Definition

    Factor V deficiency is an inherited condition that affects the ability of the blood to clot.


    Alternative Names

    Parahemophilia; Owren's disease


    Causes, incidence, and risk factors

    Normal blood coagulation is a complex process involving as many as 20 different proteins in blood plasma, which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form a protein called fibrin, which stops bleeding.

    Factor V deficiency is caused by a lack of the plasma protein Factor V. When certain coagulation factors are low or missing, the chain reaction does not take place normally. Factor V deficiency is rare, and can be caused by inheriting a defective Factor V gene or by acquiring an antibody that interferes with normal Factor V function.

    You can acquire an inhibitor of Factor V:

    • After giving birth
    • After being treated with a certain type of fibrin glue
    • After surgery
    • With autoimmune diseases and certain cancers

    Sometimes the cause is unknown.

    The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of Factor V deficiency, a family history of a bleeding disorder is a risk factor.

    Excessive bleeding with menstrual periods and after delivery often occurs. Men and women are affected equally. About 1 person per 1 million has the disorder.