Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues.
Causes, incidence, and risk factors
Folate, also called folic acid, is necessary for red blood cell formation and growth. You can get folate by eating green leafy vegetables and liver. Because folate is not stored in the body in large amounts, you need to get a continual supply of this vitamin through diet to maintain normal levels.
In folate-deficiency anemia, the red cells are abnormally large. These large cells are called megalocytes, or megaloblasts in the bone marrow. That is why this anemia can also be called
Causes of this anemia are:
- Certain medications (such as phenytoin [Dilantin], alcohol, methotrexate, sulfasalazine, triamterene, pyrimethamine, trimethoprim-sulfamethoxazole, and barbiturates)
alcoholism Crohn's disease, celiac disease, infection with the fish tapeworm, or other problems that make it difficult for your body to digest foods
- Poor dietary intake of folic acid
- Surgeries that remove certain parts of your stomach or small intestine, such as some weight-loss surgeries
In the third trimester of pregnancy, a woman may have a deficiency due to an increased need for folic acid.
Risk factors include:
- Alcoholism (which interferes with the absorption of folate)
- Eating overcooked food
- Poor diet (often seen in the poor, the elderly, and people who do not eat fresh fruits or vegetables)
The disease occurs in about 4 out of 100,000 people.