Gigantism

  • Alternative Names

    Giantism


    Symptoms

    The child will grow in height, as well as in the muscles and organs. This excessive growth makes the child extremely large for his or her age.

    Other symptoms include:

    • Delayed puberty
    • Double vision or difficulty with side (peripheral) vision
    • Frontal bossing and a prominent jaw
    • Headache
    • Increased sweating
    • Irregular periods (menstruation)
    • Large hands and feet with thick fingers and toes
    • Release of breast milk
    • Thickening of the facial features
    • Weakness

    Signs and tests
    • CT or MRI scan of the head showing pituitary tumor
    • Failure to suppress serum growth hormone (GH) levels after an oral glucose challenge (maximum 75g)
    • High prolactin levels
    • Increased insulin growth factor-I (IGF-I) levels

    Damage to the pituitary may lead to low levels of other hormones, including:

    • Cortisol
    • Estradiol (girls)
    • Testosterone (boys)
    • Thyroid hormone