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Goodpasture syndrome

  • Alternative Names

    Anti-glomerular basement membrane antibody disease; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Pulmonary renal syndrome; Glomerulonephritis - pulmonary hemorrhage


    Symptoms may occur very slowly over months or even years, but they often develop quickly over days to weeks.

    Loss of appetite, fatigue, weakness are often seen at first.

    Lung symptoms may include:

    • Dry cough, may cough up blood (bloody sputum)
    • Difficulty breathing after activity

    Kidney and other symptoms include:

    • Swelling (edema) in any area of the body
    • Burning sensation when urinating
    • Bloody urine
    • High blood pressure
    • Nausea and vomiting
    • Pale skin

    Signs and tests

    A physical examination may reveal signs of high blood pressure and fluid overload. The health care provider may hear abnormal heart and lung sounds when listening to the chest with a stethoscope.

    Urinalysis results are usually abnormal, and shows blood and protein in the urine. Abnormal red blood cells may be seen.

    The following tests may also be done:

    • Anti-glomerular basement membrane test
    • Arterial blood gas
    • BUN
    • Chest x-ray
    • Creatinine
    • Lung biopsy
    • Kidney biopsy