Encyclopedia Home / H / Histoplasmosis


  • Alternative Names

    Ohio River Valley fever


    Symptoms depend on the type of infection:

    • Acute asymptomatic pulmonary (lung) histoplasmosis -- no symptoms
    • Acute symptomatic pulmonary histoplasmosis:
      • Fever
      • Chills
      • Cough
      • Chest pain when breathing in
    • Chronic pulmonary histoplasmosis:
      • Chest pain
      • Cough, possibly coughing up blood
      • Fever
      • Shortness of breath
      • Sweating
    • Disseminated histoplasmosis:
      • Fevers
      • Headache
      • Neck stiffness
      • Mouth sores
      • Skin lesions
    • Other histoplasma symptoms:
      • Joint pain
      • Rashes
      • Skin nodules (red lumps called erythema nodosum), most often on the lower legs

    Signs and tests

    How histoplasmosis is diagnosed depends on the body parts involved. Tests that may be done include:

    • Skin biopsy
    • Blood, urine, or sputum tests to look for signs of histoplasmosis infection
    • Chest CT scan
    • Chest x-ray
    • Spinal tap to look for signs of infection in cerbrospinal fluid (CSF)