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Interstitial nephritis

  • Alternative Names

    Tubulointerstitial nephritis; Nephritis - interstitial; Acute interstitial (allergic) nephritis


    Interstitial nephritis can cause mild to severe kidney problems, including acute kidney failure. In about half of cases, people will have decreased urine output and other signs of acute kidney failure.

    Symptoms of this condition may include:

    • Blood in the urine
    • Fever
    • Increased or decreased urine output
    • Mental status changes (drowsiness, confusion, coma)
    • Nausea, vomiting
    • Rash
    • Swelling of the body, any area
    • Weight gain (from retaining fluid)

    Signs and tests

    An exam may show too much fluid under the skin or in the lungs (peripheral or pulmonary edema). The health care provider might hear abnormal sounds when listening to the heart or lungs with a stethoscope (auscultation). High blood pressure is common.

    Common tests include:

    • Arterial blood gases
    • Blood chemistry
    • BUN and blood creatinine levels
    • Complete blood count
    • Kidney biopsy
    • Urinalysis
    • Urine osmolality