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Lambert-Eaton syndrome

  • Alternative Names

    Myasthenic syndrome; Eaton-Lambert syndrome; Lambert-Eaton myasthenic syndrome; LEMS


    Symptoms

    Symptoms may include:

    • Weakness or loss of movement that can be more or less severe, including:
      • Difficulty chewing
      • Difficulty climbing stairs
      • Difficulty lifting objects
      • Difficulty talking
      • Drooping head
      • Need to use hands to get up from sitting or lying positions
    • Swallowing difficulty, gagging, or choking
    • Vision changes such as:
      • Blurry vision
      • Double vision
      • Problems keeping a steady gaze

    Symptoms related to the autonomic nervous system usually occur, and include:

    • Blood pressure changes
    • Dizziness upon standing
    • Dry mouth

    Signs and tests

    A detailed medical history will be taken to determine risk factors, such as a history of certain cancers.

    A physical examination shows:

    • Decreased reflexes
    • Possible loss of muscle tissue
    • Weakness or paralysis that gets slightly better with activity

    Tests to help diagnose and confirm the condition may include:

    • Electromyography (EMG) to test the health of the muscle fibers
    • Nerve conduction velocity (NCV) to test the speed of electrical activity along nerves