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Leydig cell tumor

  • Alternative Names

    Tumor - Leydig cell; Testicular tumor


    There may be no symptoms.

    When symptoms do occur, they can include:

    • Discomfort or pain in the testicle
    • Enlargement of a testicle or change in the way it feels
    • Excess development of breast tissue (gynecomastia) -- however, this can occur normally in adolescent boys who do not have testicular cancer
    • Heaviness in the scrotum
    • Lump or swelling in either testicle
    • Pain in the lower abdomen or back

    Symptoms in other parts of the body, such as the lungs, abdomen, pelvis, back, or brain may also occur if the cancer has spread.

    Signs and tests

    A physical examination typically reveals a firm lump in one of the testicles. When the health care provider holds a flashlight up to the scrotum, the light does not pass through the lump.

    Other tests include:

    • Blood tests for tumor markers: alpha fetoprotein (AFP), human chorionic gonadotropin (beta HCG), and lactic dehydrogenase (LDH)
    • Chest x-ray
    • CT scan of the abdomen and pelvis
    • Ultrasound of the scrotum

    An examination of the tissue is usually done after the entire testicle is surgically removed (orchiectomy).