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Macroglobulinemia of Waldenstrom

  • Alternative Names

    Waldenstrom's macroglobulinemia; Macroglobulinemia - primary; Lymphoplasmacytic lymphoma


    Plasmapheresis removes unwanted substances from the blood. In macroglobulinemia, it removes or reduces the high level of IgM, and is used to quickly control the symptoms caused by blood thickening.

    Drug therapy may include steroids, Leukeran, Alkeran, Cytoxan, fludarabine, or rituximab, or combinations of chemotherapy drugs.

    Patients who have a low number of red or white blood cells or platelets may need transfusions or antibiotics.

    Support Groups

    Expectations (prognosis)

    The average survival is about 6.5 years. Some people live more than 10 years.

    In some people, the disorder may produce few symptoms and progress slowly.

    • Changes in mental function, possibly leading to coma
    • Congestive heart failure
    • Gastrointestinal bleeding
    • Vision problems

    Calling your health care provider

    Call your health care provider if symptoms of this disorder develop.