Membranoproliferative glomerulonephritis type II is a kidney disorder causing decreased kidney function because of inflammation and changes in the tissues of the internal kidney structures.
Membranoproliferative glomerulonephritis (type II); Glomerulonephritis - membranoproliferative (type II); Mesangiocapillary glomerulonephritis (type II); Dense deposit disease; MPGN II
Causes, incidence, and risk factors
The glomeruli are the inner structures of the kidney. They include small capillaries surrounded by membranes through which the blood is filtered to form urine.
Certain cells in the capillary wall (mesangial cells) increase in number and the parts of the glomerular membranes change in structure. Type II MPGN involves deposits within the glomerular basement membrane (the "bottom" layer of the membrane).
Membranoproliferative GN II is much less common than
The effect of this disorder is very similar in both forms of MPGN. The glomerular membrane changes make the glomerulus permeable to protein and blood cells. The microscopic features of MPGN II are somewhat more variable and cellular compared to MPGN I. MPGN II also tends to get worse faster, leading more quickly to end stage renal disease than does MPGN I.
MPGN may present as
Swelling of the body may occur as sodium and water are retained in the body. Protein in the bloodstream normally keeps fluid within the blood vessels. When protein is lost, fluid leaks from blood vessels into the tissues, which contributes to
Nitrogen-containing waste products such as urea and