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Membranous nephropathy

  • Alternative Names

    Membranous glomerulonephritis; Membranous GN; Extramembranous glomerulonephritis; Glomerulonephritis - membranous; MGN


    Symptoms often begin slowly over time, and may include:

    • Edema (swelling) in any area of the body
    • Foamy appearance of urine
    • Weight gain
    • Poor appetite
    • Urination, excessive at night
    • High blood pressure
    • Fatigue

    Signs and tests

    A physical exam may show swelling (edema).

    A urinalysis may reveal protein in the urine or blood in the urine. Glomerular filtration rate (the "speed" of blood purification) is usually nearly normal.

    Other tests may be done to see how well the kidneys are working. These include:

    • Blood urea nitrogen (BUN)
    • Creatinine - blood
    • Creatinine clearance

    Albumin levels in the blood may be low. Cholesterol and triglyceride levels may be high.

    Kidney biopsy confirms the diagnosis of membranous nephropathy.

    The following tests can help determine the cause of membranous nephropathy:

    • Antinuclear antibodies test
    • Anti-double-strand DNA, if the antinuclear antibodies test is positive
    • Blood tests to check for hepatitis B, hepatitis C, and syphillis
    • Complement levels
    • Cryoglobulin test