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Multiple endocrine neoplasia (MEN) I

  • Definition

    Multiple endocrine neoplasia (MEN) type I is an inherited disorder in which one or more of the endocrine glands are overactive or form a tumor. Endocrine glands most commonly involved include:

    • Pancreas
    • Parathyroid
    • Pituitary

    Alternative Names

    Wermer syndrome; MEN I

    Causes, incidence, and risk factors

    MEN I is caused by a defect in a gene that carries the code for a protein called menin. The condition causes tumors of various glands to appear in the same person, but not necessarily at the same time.

    The disorder may occur at any age, and it affects men and women equally. A family history of this disorder raises your risk.