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Multiple endocrine neoplasia (MEN) I

  • Alternative Names

    Wermer syndrome; MEN I


    Symptoms vary from person to person, and depend on which gland is involved. They may include:

    • Abdominal pain
    • Anxiety
    • Black, tarry stools
    • Bloated feeling after meals
    • Burning, aching, or hunger discomfort in the upper abdomen or lower chest that is relieved by antacids, milk, or food
    • Decreased sexual interest
    • Fatigue
    • Headache
    • Lack of menstrual periods, infertility, or failure to produce breast milk (in women)
    • Loss of appetite
    • Loss of body or facial hair (in men)
    • Loss of coordination
    • Mental changes or confusion
    • Muscle pain
    • Nausea and vomiting
    • Sensitivity to the cold
    • Unintentional weight loss
    • Vision problems
    • Weakness

    Signs and tests

    Signs may include:

    • Coma (if low blood sugar is untreated)
    • High blood calcium level
    • Kidney stones
    • Low blood pressure
    • Low blood sugar
    • Pituitary problems (such as breast discharge from too much prolactin, a hormone that controls breast milk production)

    Tests to diagnose tumors involved with MEN I may include:

    • Blood cortisol level
    • CT scan of abdomen
    • CT scan of the head
    • Fasting blood sugar
    • Insulin test
    • MRI of the abdomen
    • MRI of the head
    • Parathyroid biopsy
    • Serum adrenocorticotropic hormone
    • Serum calcium
    • Serum follicle stimulating hormone
    • Serum gastrin
    • Serum glucagon
    • Serum luteinizing hormone
    • Serum parathyroid hormone
    • Serum prolactin
    • Serum thyroid stimulating hormone (rarely used)
    • Ultrasound of the neck