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Multiple endocrine neoplasia (MEN) I

  • Alternative Names

    Wermer syndrome; MEN I


    Surgery to remove the diseased gland is the treatment of choice. A medication called bromocriptine may be used instead of surgery for pituitary tumors that release the hormone prolactin.

    The parathyroid glands, which control calcium production, can be removed. However, because it is difficult for the body to regulate calcium levels without these glands, a total parathyroid removal is usually not done initially.

    There is now effective medication to reduce the excess stomach acid production caused by some tumors, and to reduce the risk of ulcers.

    Hormone replacement therapy is given when entire glands are removed or do not produce enough hormones.

    Support Groups

    Expectations (prognosis)

    Pituitary and parathyroid tumors are usually noncancerous (benign), but some pancreatic tumors may become cancerous (malignant) and spread to the liver. These can lower life expectancy.

    The symptoms of peptic ulcer disease, low blood sugar, excess calcium in the blood, and pituitary dysfunction usually respond well to treatment.


    Recurrent tumors may develop.

    Calling your health care provider

    Call your health care provider if you notice symptoms of MEN I or have a family history of this condition.