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Multiple endocrine neoplasia (MEN) II

  • Alternative Names

    Sipple syndrome; MEN II


    The symptoms may vary. However, they are similar to those of:

    • Medullary carcinoma of the thyroid
    • Pheochromocytoma
    • Parathyroid adenoma
    • Parathyroid hyperplasia

    Signs and tests

    To diagnose this condition, the health care provider looks for a mutation in the RET gene. This can be done with a blood test. Additional tests are done to determine which hormones are being overproduced.

    A physical examination may reveal:

    • Enlarged lymph nodes in the neck
    • Fever
    • High blood pressure
    • Rapid heart rate
    • Thyroid nodules

    Imaging tests used to identify tumors may include:

    • Abdominal CT scan
    • Imaging of the kidneys or ureters
    • MIBG scintiscan
    • MRI of abdomen
    • Radioimmune assay of parathyroid hormone
    • Thyroid scan
    • Ultrasound of the thyroid

    Blood tests are used to evaluate the function of each endocrine gland. The following tests may be performed:

    • Calcitonin level
    • Blood alkaline phosphatase
    • Blood calcium
    • Blood phosphorus
    • Urine catecholamines
    • Urine metanephrine

    Other tests or procedures that may be done include:

    • Adrenal biopsy
    • Electrocardiogram (ECG)
    • Thyroid biopsy
    • Parathyroid biopsy