• Alternative Names

    Idiopathic myelofibrosis; Myeloid metaplasia; Agnogenic myeloid metaplasia; Primary myelofibrosis; Secondary myelofibrosis


    There is no specific treatment for myelofibrosis. Treatment depends on the symptoms and degree of the low blood counts.

    The goal of treatment is to relieve symptoms. Treatment may involve:

    • Blood transfusions to correct anemia
    • Radiation and chemotherapy
    • Medicines called recombinant erythropoietin or androgens to help stimulate red blood cell production
    • Splenectomy (removal of the spleen) if swelling causes symptoms, or to help with anemia

    In young people, bone marrow or stem cell transplants appear to improve the outlook, and may cure the disease.

    Support Groups

    Expectations (prognosis)

    This disorder causes slowly worsening bone marrow failure with severe anemia. Low platelet count leads to easy bleeding. Spleen swelling may slowly get worse.

    The average survival of people with primary myelofibrosis is about 5 years. However, some people may survive for decades.

    • Acute myelogenous leukemia
    • Liver failure

    Calling your health care provider

    Call for an appointment with your health care provider if symptoms of this disorder develop. Uncontrolled bleeding, shortness of breath, or jaundice that gets worse need urgent or emergency care.