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Necrotizing vasculitis

  • Alternative Names

    Vasculitis - necrotizing


    Symptoms

    Fever, chills, fatigue, or weight loss may be the only symptoms at first. However, symptoms may be in almost any part of the body.

    Skin:

    • Abnormal skin tissue (lesions)
      • Papules (small, solid, and raised lesions)
      • Red or purple colored
      • Located on the legs, hands, or other parts of the body
    • Fingers that change color (blue fingers or toes)
    • Tissue death due to lack of oxygen
      • Pain or tenderness in the area
      • Skin redness
      • Sores (ulcers) that do not heal

    Muscles and joints:

    • Joint pain
    • Leg pain
    • Muscle contractions
    • Wasting away of muscles

    Brain and nervous system:

    • Pain, numbness, tingling in an arm, leg, or other body area
    • Weakness of an arm, leg, or other body area
    • Pupils that are different sizes
    • Eyelid drooping
    • Swallowing difficulty
    • Speech impairment
    • Movement difficulty

    Other symptoms include:

    • Abdominal pain
    • Blood in the urine or stools
    • Painful menstruation
    • Hoarseness or changing voice
    • Symptoms related to damage of the arteries that supply the heart (coronary arteries)

    Signs and tests

    The doctor will perform a physical exam. A nervous system (neurological) examination may show signs of nerve damage.

    Tests that may be done include:

    • Biopsy of the muscle, organ, tissue, or nerve biopsy
    • Chest x-ray
    • Sedimentation rate
    • Urinalysis
    • Hepatitis blood test
    • Blood test for antibodies against neutrophils (ANCA antibodies)