Not all patients need treatment. For example, patients who have abnormal blood tests only may not need treatment.
People with Paget's disease who are commonly treated include:
- Patients with deformities
- Patients with no symptoms when certain bones (such as weight-bearing bones) are involved, especially if the bony changes are progressing quickly, to reduce the risk of fractures
- Patients with symptoms
Drug therapy helps prevent further bone breakdown. Currently, there are several classes of medications used to treat Paget's disease. These include:
- Bisphosphonates -- These drugs are the first-line treatment, and they help increase bone density. Types of bisphosphonates include:
- Alendronate (Fosamax)
- Etidronate (Didronel)
- Pamidronate (Aredia)
- Risedronate (Actonel)
- Tiludronate (Skelid)
- Zoledronic acid (Zometa)
- Calcitonin -- This hormone is involved in bone metabolism. Types include:
- Intranasal (Miacalcin)
- Subcutaneous (Calcimar)
- Plicamycin (Mithracin)
Localized Paget's disease needs no treatment, if there are no symptoms and no evidence of active disease. Orthopedic surgery may be needed to correct a deformity in severe cases.
For additional support and resources, see the Paget Foundation.
Disease activity and symptoms can generally be controlled with current medications. A small percentage of patients may develop a cancer of the bone called
- Bone fractures
- Heart failure
Paraplegia Spinal stenosis
Calling your health care provider
Call for an appointment with your health care provider if you develop symptoms of Paget's disease.