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Paroxysmal cold hemoglobinuria (PCH)

  • Alternative Names


    • Chills
    • Fever
    • Back pain
    • Leg pain
    • Abdominal pain
    • Headache
    • General discomfort, uneasiness, or ill feeling (malaise)
    • Blood in the urine (red urine)

    Signs and tests

    Laboratory tests can help diagnose this condition.

    • Bilirubin levels are high in blood and urine
    • Complete blood count (CBC) shows anemia.
    • Coombs test is negative.
    • Donath-Landsteiner test is positive.
    • Level of hemoglobin is increased during attacks.
    • Lactate dehydrogenase level is high.