Encyclopedia Home / P / Paroxysmal nocturnal hemoglobinuria (PNH)

Paroxysmal nocturnal hemoglobinuria (PNH)

  • Alternative Names

    PNH


    Symptoms
    • Abdominal pain
    • Back pain
    • Blood clots -- may form in some people
    • Dark urine -- comes and goes
    • Easy bruising or bleeding
    • Headache
    • Shortness of breath

    Signs and tests

    Red and white blood cell counts and platelet counts may be low.

    Red or brown urine signals the breakdown of red blood cells and that hemoglobin is being released into the body's circulation and eventually into the urine.

    Tests that may be done to diagnose this condition may include:

    • Complete blood count (CBC)
    • Coombs' test
    • Flow cytometry to measure certain proteins
    • Ham's (acid hemolysin) test
    • Serum hemoglobin and haptoglobin
    • Sucrose hemolysis test
    • Urinalysis
    • Urine hemosiderin