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Rapidly progressive (crescentic) glomerulonephritis

  • Alternative Names

    Necrotizing glomerulonephritis; Glomerulonephritis - crescentic; Crescentic glomerulonephritis


    Symptoms

    Common symptoms include the following:

    • Edema (swelling)
      • face
      • eyes
      • ankles, feet, extremities
      • abdomen
      • generalized
    • Dark or smoke-colored urine
    • Blood in the urine
    • Decreased urine volume
    Symptoms that may also appear include the following:
    • Fever
    • Myalgia (muscle aches)
    • Arthralgia (joint aches)
    • Shortness of breath
    • Cough
    • Malaise (a general ill feeling)
    • Abdominal pain
    • Loss of appetite
    • Diarrhea

    Signs and tests

    An examination reveals edema (swelling). Circulatory overload, with associated abnormal heart and lung sounds, may be present. The blood pressure may be elevated. Rapid, worsening loss of kidney function may be present.

    • Urinalysis may be abnormal, showing blood in the urine, urine protein, white blood cells, casts, or other abnormalities.
    • The BUN and creatinine may rise rapidly.
    • The creatinine clearance decreases.
    • Anti-glomerular basement membrane antibody tests may be positive in some cases.
    • Antineutrophil cytoplasmic antibodies (ANCAs) may be present.
    • Complement levels may be decreased in some cases.
    • Other tests for suspected causes may be performed.
    • A kidney biopsy confirms crescentic glomerulonephritis.