Sarcoidosis

  • Symptoms

    There may be no symptoms. When symptoms occur, they can involve almost any part or organ system in your body.

    Almost all patients have lung or chest symptoms:

    • Dry cough
    • Shortness of breath
    • Discomfort behind your breast bone
    • Abnormal breath sounds (such as rales)

    Symptoms of general discomfort or uneasiness often occur:

    • Ill feeling (malaise)
    • Fatigue (one of the most common symptoms in children)
    • Fever
    • Weight loss (one of the most common symptoms in children)
    • Joint achiness or pain (arthralgia)

    Skin symptoms:

    • Skin rashes
    • Old scars become more raised
    • Raised, red, firm skin sores (erythema nodosum), almost always on the front part of the lower legs
    • Skin lesions
    • Hair loss

    Nervous system (neurological) and vision changes:

    • Headache
    • Seizures
    • Weakness or paralysis (palsy) on one side of the face
    • Eye burning, itching, and discharge
    • Symptoms of uveitis
    • Decreased tearing

    Other symptoms of this disease:

    • Enlarged lymph glands (armpit lump)
    • Enlarged liver
    • Enlarged spleen
    • Dry mouth
    • Nosebleed

    Signs and tests

    Often the disease is found in patients with no symptoms who have an abnormal chest x-ray.

    Different imaging tests may help diagnose sarcoidosis:

    • Chest x-ray to see if the lungs are involved or lymph nodes are enlarged
    • CT scan
    • Lung gallium (Ga.) scan

    Biopsies of different tissues may be done:

    • Lymph node biopsy
    • Skin lesion biopsy
    • Bronchoscopy to perform a biopsy
    • Open lung biopsy
    • Mediastinoscopy with biopsy
    • Liver biopsy
    • Kidney biopsy
    • Nerve biopsy
    • Heart biopsy

    This disease may also alter the results of the following lab tests:

    • CBC
    • Chem-7 or chem-20
    • Quantitative immunoglobulins (nephelometry)
    • PTH
    • Serum phosphorus
    • Immunoelectrophoresis - serum
    • Calcium - urine
    • Calcium - ionized
    • Calcium - serum
    • Liver function tests