Sclerosing cholangitis refers to swelling (inflammation), scarring, and destruction of the
Primary sclerosing cholangitis; PSC
Causes, incidence, and risk factors
In this condition, the bile ducts inside and outside the liver become narrowed and scarred.
The cause is often unknown.
The disease is often seen in patients who have:
- Inflammatory bowel disease (
Crohn's diseaseand ulcerative colitis) Sarcoidosis Chronic pancreatitis
- Many autoimmune disorders
Genetic factors may also be responsible. Sclerosing cholangitis occurs more often in men than women. This disorder is rare in children.
Sclerosing cholangitis may also be caused by:
- Toxicity from chemicals, copper, bile acids
- Infections in the liver, gallbladder, and bile ducts