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Sclerosing cholangitis

  • Alternative Names

    Primary sclerosing cholangitis; PSC


    The first symptoms are usually fatigue, yellowing of the skin and eyes (jaundice), and itching. However, some people may have no symptoms.

    Other symptoms may include:

    • Loss of appetite and weight loss
    • Enlarged liver
    • Enlarged spleen
    • Repeat episodes of cholangitis

    Signs and tests

    Some people do not have symptoms, but blood work reveals they have abnormal liver function. The doctor will rule out diseases that cause similar problems. For example, you will be checked for stones in the gallbladder or biliary tract.

    Tests that show cholangitis include:

    • Abdominal CT scan
    • Abdominal ultrasound
    • Endoscopic retrograde cholangiopancreatography (ERCP)
    • Liver biopsy
    • Magnetic resonance cholangiopancreatography (MRCP)
    • Percutaneous transhepatic cholangiogram (PTC)

    Blood tests include:

    • Elevated liver enzymes (liver function tests)