There is no known way to prevent the development of serum sickness.
People who have experienced serum sickness, anaphylactic shock, or drug allergy should avoid future use of the antiserum or drug.
Salmon JE. Mechanisms of immune mediated tissue injury. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 44.