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Thrombocytopenia - drug induced

  • Definition

    Thrombocytopenia is any disorder in which there are not enough platelets. Platelets are cells in the blood that help the blood clot. A low platelet count makes bleeding more likely.

    When drugs or medications are the causes of a low platelet count, it is called drug-induced thrombocytopenia.

    See also: Thrombocytopenia

    Alternative Names

    Drug-induced thrombocytopenia

    Causes, incidence, and risk factors

    Drug-induced thrombocytopenia occurs when certain drugs or medications destroy platelets or interfere with the body's ability to make enough of them.

    There are two types of drug-induced thrombocytopenia:

    • Immune
    • Nonimmune

    If a drug causes your body to produce antibodies, which seek and destroy your platelets, the condition is called drug-induced immune thrombocytopenia. Heparin, a blood thinner, is probably the most common cause of drug-induced immune thrombocytopenia.

    If a medicine prevents your bone marrow from making enough platelets, the condition is called drug-induced nonimmune thrombocytopenia. Chemotherapy drugs and a seizure medication called valproic acid may lead to this problem.

    Other drugs that cause drug-induced thrombocytopenia include:

    • Furosemid
    • Gold, used to treat arthritis
    • Nonsteroidal anti-inflammatory drugs (NSAIDs)
    • Penicillin
    • Quinidine
    • Quinine
    • Ranitidine
    • Sulfonamides