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Toxic nodular goiter

  • Alternative Names

    Toxic multinodular goiter; Plummer's disease


    Symptoms are those of hyperthyroidism. However, the bulging eyeballs seen in Graves disease do not occur.

    Symptoms include:

    • Fatigue
    • Frequent bowel movements
    • Heat intolerance
    • Increased appetite
    • Increased sweating
    • Menstrual irregularities (in women)
    • Muscle cramps
    • Nervousness
    • Restlessness
    • Weight loss

    Signs and tests

    A physical examination will show one or many nodules in the thyroid. There may be a rapid heart rate.

    Other test results:

    • Serum thyroid hormone levels (T3, T4) are high.
    • Serum TSH (thyroid stimulating hormone) is low.
    • Thyroid scan shows that the nodules are taking up increased amounts of radioactive iodine.