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Toxic nodular goiter

  • Alternative Names

    Toxic multinodular goiter; Plummer's disease


    Treatments include:

    • Antithyroid drugs (propylthiouracil, methimazole)
    • Radioactive iodine
    • Surgery

    Beta blockers (propranolol) can control some of the symptoms of hyperthyroidism until thyroid hormone levels in the body are under control.

    Support Groups

    Expectations (prognosis)

    Because toxic nodular goiter is mainly a disease of the elderly, other chronic health problems may influence the outcome of this condition. The elderly person may be less able to tolerate the effect of hyperthyroidism on the heart.


    Heart complications:

    • Atrial fibrillation
    • Congestive heart failure
    • Rapid heart rate

    Other complications:

    • Bone loss leading to osteoporosis

    Thyroid crisis or storm is an acute worsening of hyperthyroidism symptoms. It may occur with infection or stress. Thyroid crisis may cause:

    • Abdominal pain
    • Decreased mental alertness
    • Fever

    Immediate hospitalization is necessary.

    Complications of having a very large goiter may include difficulty breathing. This is due to pressure on the airway passage that lies behind the thyroid.

    Calling your health care provider

    Call your health care provider if you have symptoms of this disorder. Follow the health care provider's recommendations for follow-up visits.