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Von Willebrand disease

  • Symptoms
    • Abnormal menstrual bleeding
    • Bleeding of the gums
    • Bruising
    • Nosebleeds
    • Skin rash

    Signs and tests

    Tests that may be done to diagnose this disease include:

    • Bleeding time (is prolonged)
    • Platelet aggregation test
    • Platelet count (may be low or normal)
    • Ristocetin cofactor test (the primary assay test used to diagnose von Willebrand disease)
    • Von Willebrand factor level (level is reduced)

    This disease may also alter the results of the following tests:

    • Factor VIII level
    • Von Willebrand factor multimers (parts of the von Willebrand factor protein molecule)

    Von Willebrand disease may be hard to diagnose. Low von Willebrand factor levels and bleeding do not always mean you have von Willebrand disease.