Updates in ED Research

David Knowles, M.D. Health Pro
  • Hi everyone. I would like to share with you some interesting things that have been announced recently for those of you impacted by ED.

    New Research
    Investigators from Albert Einstein College of Medicine in New York led by Dr. Arnold Melman have recently presented early data that gene therapy for Erectile Dysfunction is safe and has some efficacy. They have completed the early research studies where people receive increasing doses of treatment to determine if the new gene therapy is safe. At high doses, where they were able to see some efficacy, no patient had any adverse reactions from the treatment. This new avenue of treatment involves injecting small sections of DNA directly into the penis to change the genes of the patient. These genetic changes then help the patient’s own tissues work more normally and achieve functional erections. These are preliminary studies and more studies have to be performed but physicians and researchers are excited about the early results. I will keep you updated.
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    Oral Medication Safety
    There has been recent concern that the oral medications for ED may cause blindness, caused by non-arteritic anterior ischemic optic neuropathy (NAION). The Pfizer Corporation has directly investigated this problem. They gathered data from over 103 previous studies and found that the chances of having NAION while taking sildenafil (Viagra) is equal to that of the general population not taking the medication. The earlier reports may have demonstrated a link between the use of sildenafil and NAION because the two diseases share the same risk factors. Both ED and NAION are more likely in patients with hypertension (high blood pressure), diabetes, hyperlipidemia (high cholesterol) and smoking. This study was not an ideal study but does give some reasonable evidence that the drug may not actually be the cause of the eye problem. The risk of having NAION with or without the use of sildenafil is still only 0.000028% .

    Premature Ejaculation
    Researchers from the Institute of Urology, University of Sao Paulo have presented some interesting research for premature ejaculation. They studied the combination of tadalafil (Cialis) and slow release fluoxetine (Prozac) in patients with premature ejaculation. They were able to show that the combination of both medications increased the time of intercourse doubled when the two medications were given together. When the patient’s only received Cialis or Prozac alone the average time of intercourse was 207 and 230 seconds respectively. When these medications were given together the average length of intercourse increased to 464 seconds. The mechanism by which Cialis increases the length of time one is able to prolong ejaculation is not currently known but it is believed the increased reliability and strength of the erections increases the confidence of the patient and improves their overall performance. Larger studies are needed but these results are promising for a disease that has previously had few good treatment options.

  • I look forward to hearing from you at feedback@erectiledysfunction.com and answering any questions that you might have.
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Published On: June 22, 2006