There is some concern that replacement therapy may increase the risk for the following adverse effects, particularly in men with normal testosterone levels:
- Lower HDL (the so-called good cholesterol)
- Rapid growth of prostate tumors in men with existing prostate cancers. (Taking testosterone does not appear to increase the risk for prostate cancer, but experts remain concerned.)
- Lower sperm count
- Possible cause of sleep apnea
- Possible increased risk for polycythemia, an abnormal increase in red blood cells
- Possible increased risk for benign prostatic hyperplasia
In men with normal male hormone levels, replacement therapy also does not appear to improve bone mass or muscle strength.


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