As both a blogger and a patient "living with heart disease" the recent announcement (see HealthCentral.com report) of the success of the new anti-cholesterol drug "eprotirome" is the most exciting news I have come across in quite some time. However, the article's headline "Statin Alternative Shows Promise in New Study" tells only half the story!
Eprotirome is an experimental thyroid hormone mimetic (a drug that "mimics" the action of thyroid hormones) that significantly lowered LDL cholesterol during Phase 2 clinical trials. Cutting-edge physicians such as HeartCentral.com expert and cardiologist William R. Davis have demonstrated for some time now that aggressively treating even mild or sub-clinical hypothyroidism (a condition where the body does not produce enough of natural thyroid hormones) can help combat heart disease in several ways.
Unfortunately, there is a limit to how much synthetic thyroid hormone you can take before you exhibit the symptoms of hyperthyroidism (too much thyroid hormone) which has it own set of negative cardiac side effects such as heart arrhythmias! But, what if you could develop a drug that only mimicked thyroid hormones on some organs such as the liver where cholesterol and other lipids are manufactured. That is essentially what eprotirome does.
During a 12-week study conducted by Karo Bio AB, 168 participants where given either a placebo or one of three doses of eprotirome along with a statin. LDL Cholesterol levels were lowered up to an additional 32% over baseline with just a statin alone with none of the adverse effects generally associated with increasing levels of thyroid hormones.
This result is certainly something to be ecstatic about as there are many people for whom statins do not provide needed reductions in LDL Cholesterol or who simply cannot tolerate the side effects of statins. However, there was another, under-reported and under-emphasized outcome in the study - and now, as Paul Harvey used to say, here is, "the rest of the story!"
Near the end of the article Dr. Paul Ladenson, professor of endocrinology and metabolism at the Johns Hopkins University School of Medicine (and lead author of a report on the trial, published in the New England Journal of Medicine) offered this observation which I believe to be the "money" quote, "The second exciting part is its impact on lipids other than LDL cholesterol. Though statins lower LDL ("bad") cholesterol, they have no effect on other blood fats, such as lipoprotein A, which is believed to be equally damaging . . ." Eprotirome not only exhibited a dose dependent effect on lowering LDL Cholesterol it showed a similar effect on lowering Lipoprotein(a), recently discovered to be an independent risk factor for heart disease.
For those not familiar with Lipoprotein(a), often referred to as "Lp(a)," it is an LDL-like particle that has now been shown to greatly magnify the risk of Coronary Artery Disease (CAD) and is especially identified with very early CAD and hearts attacks - for some as young as their thirties and forties! Lp(a) is almost entirely genetic in cause, is resistant to changes in diet and exercise, and there are no safe therapeutic agents capable of reliably lowering it. Niacin is the most well known anti-Lp(a) agent but is often incapable of persistently lowering Lp(a) to acceptable levels.