If the heart is thickened due to valvular blockage (aortic valve stenosis) the treatment involves relief of the blockage. When surgery is appropriately planned this is quite successful. The most common cause of left ventricular hypertrophy, however, is inadequately controlled hypertension. Control of blood pressure with medications to appropriate levels will often reverse the process and return the thickness of the heart to more normal size. For hypertrophic cardiomyopathy and Fabry's disease, there are medical treatments that more appropriately address the problem. Whatever the cause, it is important to commence the correct therapy for a thickened heart under the care of a cardiologist, and obtain follow up to make sure the excess thickening is regressing.

