I have the same problem; HDL 108 and LDL 160-199; no history of heart disease in my family but all of my siblings have same condition; (I am age 51 and a ICU nurse) and I can't seem to find information in the medical community either as to what may be harmful. HDL 100 is the limit for HDL measurment so I've been told that you can't get any more negative risk than that. I was told that if I went on statins (cholesterol lowering meds) that it would likely lower the HDL too and thus PUT me at risk for heart disease so this is uncharted territory... sooo what to do? I'm trying omega-3 suppliments; I'm taking 1200mg (2 capsules) daily for one year and then going to recheck my cholesterol levels and see if it does any good at lowering the LDL; it shouldn't affect the HDL; What you'll want to do is have your total cholesterol fractionated which is a more comprehensive test of the individual sub catagories of HDL and more importantly the VVLDL subcatagories of LDL molecules; I had one done by my doctor 3 years ago; Its a pricey test but is worth it; I'll have this one done again after my omega-3 fatty acids trial. You can find it in the pharmacy section of your grocers ( don't bother the GNC outlets as their suppliments are no better than the grocers and more pricey) you can get a jumbo bottle at Costco if you have one nearby, at a reasonable price. good luck Helen