FROM OUR EXPERTS
For years people with a high risk for heart disease have relied on aspirin as part of their health regimen. Lately, there have been numerous news stories based on the recent POPADAD Trial that trumpet that aspirin is of no benefit in reducing first heart attacks. Let's clear the air and separate the science from the hysteria - and also look at a major flaw in this and other studies like it.
The POPADAD Trial found "no evidence that aspirin or antioxidants are of any benefit in the primary prevention of cardiovascular events in diabetic patients with asymptomatic peripheral arterial disease (PAD) ." However, the study's author did comment there was a benefit for those who had established heart disease as evidenced by a previous cardiac event. Remember, this last sentence. It will be the key to pointing out a major flaw in heart disease studies and treatment.
First of all, the study looked only at patients with diabetes and asymptomatic PAD as ...
Like most of you, I take aspirin daily, 162.5mg (it used to be 325 until my stomach rebelled). Most cardiologists recommend aspirin for heart disease sufferers.
Aspirin works by interfering with the generation of thromboxane A2 (TXA2) which is needed for platelet aggregation (clotting). The COX-1 enzyme acts on arachidonic acid (AA) to produce endoperoxides that in turn produce TXA2. Aspirin interferes with the generation of TXA2 by irreversably acetylating the platelet COX-1 enzyme thereby blocking its access to AA. Because platelets are anucleate , they cannot generate additional COX-1. In the absence of TXA2, platelet aggregation does not occur. Got all that?! Most practitioners prescribe anywhere from 81mg to 325mg for heart patients. Studies such as CURE suggest 81mg is optimal. The ISIS-2 study puts the dose at 162mg (for recent heart attack sufferers) and, frankly, since aspirin is so cheap, many simply make the leap to "more must be better." Ahh, but there are downsi...
Generic Name: ASPIRIN/ACETAMINOPHEN/CAFFEINE - ORAL Pronounced: (AS-pir-in/a-SEET-a-MIN-oh-fen/KAF-een) Aspirin-Acetaminophen-Caffeine Oral Interactions
See also Warning section.
If you are taking this medication under your doctor's
direction, your doctor or pharmacist may already be aware of any possible drug
interactions and may be monitoring you for them. Do not start, stop, or change
the dosage of any medicine before checking with your doctor or pharmacist
(See also adult maximum daily dose information in Side
This drug should not be used with the following
medications because very serious interactions may occur:
If you are currently using any of these medications listed
above, tell your doctor or pharmacist before starting this
Before using this medication, tell your doctor or
pharmacist of all prescription and nonprescription products you ma...
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