This is something you DEFINITELY need to ask the doctor.  The internet is not the correct forum for questions like this--it is too complicated, and you don't know who you are corresponding with.  You also need to clearly explain EVERYTHING you are experiencing and when.  Good to keep a journal, as it makes  it easier to remember what to bring up.

Thanks for your question.  I thought  you would like to read the drug information on both zestril and wellbutrin.

Zestril: This drug belongs to a group of medications called ACE inhibitors. It is used to treat high blood pressure (hypertension) in adults and in children 6 years of age and older. It works by relaxing blood vessels, causing them to widen. High blood pressure reduction helps prevent strokes, heart attacks and kidney problems.

Wellbutrin: Bupropion is used to treat depression. It can improve your mood and feelings of well-being. It may work by helping to restore the balance of certain natural chemicals (neurotransmitters) in your brain.

Hope this helps and all the best, sue

Hi Snowolf83607,

There are no major interactions between wellbutrin, ibuprofen, and zestril. It is possible that the discovery of your health conditions has caused you to go back to feeling the same way you did before starting the Wellbutrin. As for your chest pain, I would talk to your doctor as soon as possible.

Thanks for your question!

Jill

There can be some interaction between bupropion (Wellbutrin) and lisinopril (Zestril).  Wellbutrin can have some effects on the chemical makeup in the brain and can cause a (usually) small decrease in blood pressure.  While the Zestril is being used for blood pressure, it can drop it too much, which might explain the reason for the increased heart rate.  Together these medications can cause additive effects such as drowsiness, dizziness, lightheadedness, confusion, or a drop in blood pressure particularly when getting up from a sitting position.  Notify your doctor about the symptoms you are experiencing.