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I have had severe migraines for over 25 years and have gone to the same doctor for 35. After years of medications not working and taking over 1,600 MG of Advil a day, nothing worked until she gave me hydrocodone 10/325. My migraines the week before my period will be daily for 4-5 days and then I usually have a migraine 1 - 2 days every week. She has given me 30 pills a months for 4 years, with the notes to take 1-2 pills every 4 hours as needed. Well when I have the 4-5 days I will take approx. in those days 20-25 pills depending on when they hit. If it is closer to the weekend I can knock it out in 2 days. During the week I try to manage only taking meds at night. So over the last 25 years I now find that I need to take 2 pills at a time. I have asked that she increase me meds to 45 pills per month. She has refused and now wants me to sign a controlled substance agreement. She says she is concerned amount her medical license. Obviously not my pain or her patient. She ...
I generally don't make a practice of reporting on new drugs that are still in the clinical trial phases of development because it takes so many years to bring a new drug to market and you never know what might happen to them along the way. But there are two new drugs in the final phase of clinical trials that I find particularly interesting and promising. Although it will still be at least three to five years before they might be approved, I thought you might like to know about them. Controlled-Release Hydrocodone The first is a controlled-release hydrocodone being developed by Zogenix, Inc. Hydrocodone is the most widely prescribed drug in the U.S., but there are two things that make this new drug unique:
It is just hydrocodone, with nothing added. Currently you can only get hydrocodone combined with either acetaminophen or ibuprofen.
It is a controlled-release formulation for people who require round-the-clock pain relief. Right now, h...
Long term use of the painkiller ibuprofen when taken for more than five years has been found to decrease the risk of Alzheimer's disease by 40 percent. Published in the
Journal of Neurology, this large scale study demonstrated that the type of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) was important in risk reduction. They found some NSAIDs less effective than others. Indomethacine only reduced risk of Alzheimer's by 25 pecent and Pfizer's Celebrex and Celecox had no effect at all.
The newly published study looks at work carried out by researchers from Boston University School of Medicine, Boston University School of Public Health and Bedford Veterans Affairs Medical center. It involved over 49,000 veterans aged 55 years and older.
The ibuprofen group of medicines include brand names such as Advil, Motrin and Nurofen. NSAIDs are one of the most widely used drugs for pain relief of non-serious arthritic conditions, for rheumatic or muscular pain, backache...
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