FROM OUR EXPERTS
Ladies and gentlemen, welcome to the Heavyweight Pain Reliever Championship Match. In the blue corner, weighing in at 200 mg's is the most common NSAID (non-steroidal anti-inflammatory) found anywhere, ibuprofen . In the red corner, weighing in at a small, but mighty, 10 mg's is the most popular, most commonly prescribed opioid, hydrocodone . Today's match promises to be a real bell ringer. Who is the fastest? Who lasts the longest? Who can go the distance? Who packs the biggest punch? This decisive match will determine whether or not NSAID's or Opioids are the best pain relievers on the planet.
ROUND 1: Both the NSAID and the Opioid are off to a fast and furious pace; their analgesic onset is roughly equivalent in speed. Within the half hour, both have started to provide pain relief. At just a little over one hour, both appear to be at full strength and hitting equally hard. This fight should be one for the record books folks. Ding. Ding.
ROUND 2: With round 1 being...
Earlier this month, the FDA's Anesthetic and Analgesic Drug Products Advisory Committee overwhelmingly voted against recommending approval of Zohydro ER, an extended-release version of hydrocodone. If approved, Zohydro ER would have been the first hydrocodone medication available that did not also contain a non-opioid analgesic such as acetaminophen or ibuprofen.
While the FDA does not have to follow the recommendation of its advisory committee, it usually does. The final determination is expected to be made by March 1, 2013.
Despite the fact that Zohydro ER was studied in nearly 1,500 patients––some for as long as a year––and found to be generally safe and well-tolerated with no new or unexpected safety problems, panel members expressed concerns with potential abuse, addiction and long-term safety.
It was noted that the manufacturer didn't offer any solution as to how they would limit unintended use other than the already tight distributio...
I generally don't make a practice of reporting on new drugs that are still in the clinical trial phases of development because it takes so many years to bring a new drug to market and you never know what might happen to them along the way. But there are two new drugs in the final phase of clinical trials that I find particularly interesting and promising. Although it will still be at least three to five years before they might be approved, I thought you might like to know about them. Controlled-Release Hydrocodone The first is a controlled-release hydrocodone being developed by Zogenix, Inc. Hydrocodone is the most widely prescribed drug in the U.S., but there are two things that make this new drug unique:
It is just hydrocodone, with nothing added. Currently you can only get hydrocodone combined with either acetaminophen or ibuprofen.
It is a controlled-release formulation for people who require round-the-clock pain relief. Right now, h...
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