Ronnie Martin,

Thanks for your question.

Actonel 150 mg is a once a month medication used in the treatment and prevention of osteoporosis.  The major side effects associated with this drug include gastrointestinal symptoms of heartburn, stomach pain, esophagitis, nausea and diarrhea.  These are the most common side effects and are seen quite often.  Taking a proton pump inhibitor like prilosec, prevacid or aciphex, a few days before and few days after may be helpful in preventing these symptoms.  You cannot take any other drug or food within 45 minutes of taking this medication.

Micardis is a medication used in the treatment of high blood pressure and some cardiac conditions.  Dyspepsia (heartburn) is also described as a side effect, though most patients tolerate this drug without problems. 

I have not found any documentation that Actonel interacts with Micardis in any way, though both can cause GI side effects. 

So, your wife's symptoms may be due to gallbladder disease, or may be secondary to her medication (in part or in whole).  Be sure to discuss this with your doctor(s) before considering surgery (unless she has definite gallbladder disease such as stones).  Taking her gallbladder out may not solve her problems if the real cause is the medication(s). 

I hope this has been helpful.

Martin Cane, M.D.