Heart disease medications include both anti-clotting medications, which are used to break up blood clots at any stage of heart disease, as well as other medications, such as nitrates, beta-blockers, CCBs, ACE inhibitors, statins and other lipid-lowering drugs. Anti-clotting drugs are categorized as antiplatelets or anticoagulants. Aspirin is the most common anti-clotting drug, and nearly everyone with heart disease or at-risk for heart disease is recommended to take a low-dose aspirin daily.