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Monday, November 23, 2009
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Percodan Oral

Drug Interactions


Generic Name: OXYCODONE/ASPIRIN - ORAL
Pronounced: (ox-ee-KOH-doan/AS-pir-in)

Percodan Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

  • buprenorphine
  • butorphanol
  • mifepristone
  • nalbuphine
  • pentazocine
  • naltrexone
  • ketorolac


If you are currently using any of these medications, tell your doctor or pharmacist before starting this product.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • alcohol
  • ACE inhibitors (e.g., captopril, lisinopril, benazepril)
  • acetazolamide
  • heparin
  • warfarin
  • phenytoin
  • valproic acid
  • beta blockers (e.g., atenolol, propranolol)
  • water pills (diuretics such as furosemide, hydrochlorothiazide)
  • methotrexate
  • 6-mercaptopurine
  • nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen, celecoxib)
  • probenecid
  • sulfinpyrazone
  • insulin
  • certain diabetes medications (e.g., glyburide, glipizide)
  • corticosteroids (e.g., prednisone, prednisolone, dexamethasone)
  • pemetrexed
  • ticlopidine
  • SSRI antidepressants (e.g., fluoxetine, sertraline, citalopram)
  • lepirudin
  • live varicella virus vaccine
  • cimetidine


Tell your doctor or pharmacist if you also take drugs that may cause drowsiness, slow your breathing, or lower your blood pressure such as:

  • antihistamines that cause drowsiness (e.g., diphenhydramine)
  • anti-anxiety drugs (e.g., diazepam)
  • anti-seizure drugs (e.g., carbamazepine)
  • medicine for sleep (e.g., sedatives, hypnotics)
  • muscle relaxants
  • other narcotic pain relievers (e.g., codeine)
  • psychiatric medicines (e.g., phenothiazines such as chlorpromazine, tricyclics such as amitriptyline)
  • tranquilizers


Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

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