Thiazide diuretics, like hydrochlorothiazide and chlorthalidone, are extremely popular medications, often regarded as first-line agents in treatment of blood pressure.

When someone is first diagnosed with high blood pressure (hypertension), they are often first placed on a thiazide diuretic. Alternatively, thiazide diuretics are frequently added to other blood pressure-reducing agents to further reduce blood pressure.

This practice became well-established in blood pressure treatment with the...