High Blood Pressure Controversy: Wading Through the Muck

  • High blood pressure (hypertension) is a very common condition in Western civilization. It is strongly associated with stroke, dementia and heart attack. It is quite treatable. Yet many studies suggest that a third of the over fifty million Americans with hypertension aren't aware of their diagnosis, and another third are not being treated effectively. So what's the problem?

    Hypertension isn't a disease-it's a description. It's a measurement. It requires an intact animal to measure and to study. It can't be studied in a test tube or measured in blood. What constitutes high blood pressure hasn't remained the same. The threshold for "high" is much lower than it was twenty years ago. Different professional organizations (American Heart Association, American Diabetes Association, American Society for Hypertension) define hypertension differently and suggest different goals for treatment. Patients and often their physicians are confused about where their pressure should be and how to get there.

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    Most people are aware that their blood pressure is reported as two numbers. The higher number is the "systolic" pressure and the lower number the "diastolic" pressure. The difference between systolic and diastolic pressure is called the "pulse pressure." Most early research focused on diastolic pressure and early trials used diastolic pressure to determine the blood pressure lowering effects of anti-hypertensive drugs. These trials were performed largely in middle-aged men. We now know that particularly as patients age their systolic blood pressure is a much more important indicator of their risk for vascular disease. Pulse pressure is also a strong predictor of risk for heart attack and stroke. As we age (at least in Western cultures) there is a gradual rise in systolic blood pressure. Physicians were formerly trained that this is a "normal" phenomenon and that we should not treat hypertension in the elderly with the same vigor as in younger patients. We now know that there is no age at which blood pressure lowering does not provide benefit - a recent trial of patients in their eighties showed that blood pressure lowering reduced their risk for stroke and heart attack.

    Even how we measure blood pressure has become controversial. A recent trial suggested that measuring blood pressure in the upper arm often does not reflect the pressure in the aorta and blood vessels supplying the heart, brain and kidneys ("central blood pressure"). Disease in these vessels causes heart attack, stroke and chronic kidney disease. Importantly some very widely used blood pressure lowering drugs used in that trial did not lower central blood pressure as well as arm ("brachial") pressure. These drugs were not as effective in reducing risk for heart attack and stroke as drugs with more pronounced effects on aortic pressure. Does the blood pressure measured in the doctor's office reflect our pressure at home or at the office? Should we measure our pressure in the morning (when it is usually the highest) or later in the day? Before or after exercise or after taking our medicines? Is it important that our blood pressure "dip" at night while we sleep (probably yes)?

  • Finally, doctors don't really know if it matters how we lower blood pressure. It remains controversial if use of one class of blood pressure lowering drugs prevents heart attack and stroke more effectively than another. In other words is it how low you go or how you go low? We often hear that certain patient groups (for example the elderly or African-Americans) respond better to one class of anti-hypertensive agents than another. Is this real or marketing hype?

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    It's very confusing. Fortunately many of these controversies are being evaluated in large ongoing clinical trials and we'll be getting some answers in the next few years. In the meantime what can concerned patients do?

    First and foremost is to know your blood pressure, preferably your blood pressure at home or at least away from the doctor's office. Second is to realize that like most vascular diseases, hypertension is a lifestyle disease and that one can impact their blood pressure by simply living well. Every pound you lose generally lowers your blood pressure by a millimeter. Following a so-called Mediterranean diet will lower your blood pressure. Regular exercise lowers your blood pressure. Limiting salt intake for most patients is a cornerstone of blood pressure management. Dietary calcium, potassium and magnesium intake affects blood pressure. A flurry of recent studies suggest that vitamin D deficiency is an important cause of not only hypertension but also other vascular diseases.


    Blood pressure is one of several risk factors for heart attack and stroke and every patient with high blood pressure should know their cholesterol and blood sugar and manage it while they manage their hypertension. This concept is called global risk reduction. Finally, you need to work with a doctor knowledgeable in blood pressure management willing to work with you to help achieve your goals. It takes some effort but it's a very treatable disease.


    Related posts:

    Pulse Rate and High Blood Pressure: Defining the Connection

    High Blood Pressure Diet: Top 4 Foods to Avoid

    High Blood Pressure: 9 Steps to Rein in Skyrocketing Numbers

    Melatonin: Natural Supplement to Lower High Blood Pressure?



Published On: August 15, 2008